Nano Polymers Developed Can Prevent Heart Failure.

 Nano Polymers Developed Can Prevent Heart Failure.

Nano Polymers Developed Can Prevent Heart Failure. -Gurion University (BGU) and researchers at Sheba Medical Center, atherosclerosis, arterial plaque and reduce inflammation in the cardiovascular system to prevent heart failure new biomedical polymer and have developed a new method to treat

Atherosclerotic cardiovascular disease (

heart disease, which causes heart failure, causes 56 million deaths a year, according to the 2015 Lancet Global Diseases Report. The arteries are lined with a thin layer of cells called” endothelium " that maintain regular and blood flow. Atherosclerosis begins with damage to the endothelium and is caused by high blood pressure, smoking, or high cholesterol. The resulting damage causes plaque formation.

When inflammation is seen in endothelial cells, it brings white blood cells (monocytes) to the area and causes plaque accumulation in the arteries "E-selectin” they produce a molecule called.

Prof. from BGU Department of Clinical Biochemistry and Pharmacology “The E-selectin targeting polymer reduces existing plaque and prevents arterial thrombosis, ischemia, myocardial infarction, further plaque progression and inflammation,” says Ayelet David.

This innovative nano-polymer has many advantages.

First, it targets damaged tissues and does not damage healthy tissues. Currently, there are several available treatment options for atherosclerosis, but no other treatment reverses arterial damage and improves the heart muscle. Finally, the polymer has no side effects, unlike statins, which are still the main drug used to treat atherosclerosis.

At the patented and preclinical stage, the new polymer was tested in mice and gave a positive result. In a study sent for publication, researchers treated atherosclerotic mice with four injections of the new biomedical polymer and tested the change in their arteries after four weeks. “We were amazed by the results,”David said. "The treated mice had greatly improved myocardial function, with less inflammation and a significant reduction in artery thickness.”

Prof. Professor David and director of the Cardiovascular Research Institute of Sheba Medical Center and Professor of Cardiology at Tel Aviv University Dr. David and partner Prof. This polymer-based treatment can also help people with diabetes, hypertension and other ages, Jonathan Leor said. “Thus, the new polymeric method could have life-changing benefits for millions of people,” the researchers say.

BGN Technologies (BGN) deputy general manager of Business Development Dr. “We are looking for a pharmaceutical company to bring our polymer treatment to the next stages of drug development and ultimately market it,” Ora Horovitz said. "We believe this therapy has the potential to help a large number of people.”